Marburg and Ebola viruses
نویسنده
چکیده
PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). (c) Oxford University Press, 2014. All Rights Reserved. Under the terms of the l icence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy).date: 14 October 2014 Publisher: Oxford University Press Print Publication Date: Jul 2011 Print ISBN-13: 9780198570028 Published online: Jul 2011 DOI: 10.1093/med/9780198570028.001.0001
منابع مشابه
The origin and evolution of Ebola and Marburg viruses.
Molecular evolutionary analyses for Ebola and Marburg viruses were conducted with the aim of elucidating evolutionary features of these viruses. In particular, the rate of nonsynonymous substitutions for the glycoprotein gene of Ebola virus was estimated to be, on the average, 3.6 x 10(-5) per site per year. Marburg virus was also suggested to be evolving at a similar rate. Those rates were a h...
متن کاملHow severe and prevalent are Ebola and Marburg viruses? A systematic review and meta-analysis of the case fatality rates and seroprevalence
BACKGROUND Ebola and Marburg virus diseases are said to occur at a low prevalence, but are very severe diseases with high lethalities. The fatality rates reported in different outbreaks ranged from 24-100%. In addition, sero-surveys conducted have shown different seropositivity for both Ebola and Marburg viruses. We aimed to use a meta-analysis approach to estimate the case fatality and seropre...
متن کاملVaccine to confer to nonhuman primates complete protection against multistrain Ebola and Marburg virus infections.
Filoviruses (Ebola and Marburg viruses) are among the deadliest viruses known to mankind, with mortality rates nearing 90%. These pathogens are highly infectious through contact with infected body fluids and can be easily aerosolized. Additionally, there are currently no licensed vaccines available to prevent filovirus outbreaks. Their high mortality rates and infectious capabilities when aeros...
متن کاملEbola and Marburg Viruses: A View of Infection Using Electron Microscopy
More than 25 years have passed since the discovery of a filovirus, Marburg virus, which caused an epidemic of hemorrhagic fever among laboratory workers in Marburg, Germany, in 1967. The persons affected had contact with the blood or tissues of monkeys or with other infected persons. Marburg virus has reappeared only three times since its discovery, with the largest and most recent outbreak occ...
متن کاملDrug targets in infections with Ebola and Marburg viruses.
The development of antiviral drugs for Ebola and Marburg viruses has been slow. To date, beyond supportive care, no effective treatments, prophylactic measures, therapies, or vaccines are approved to treat or prevent filovirus infections. In this review, we examine the current treatments available to administer care for filovirus infection, the potential therapeutic targets that can be used for...
متن کاملStatus and challenges of filovirus vaccines.
Vaccines that could protect humans against the highly lethal Marburg and Ebola viruses have eluded scientists for decades. Classical approaches have been generally unsuccessful for Marburg and Ebola viruses and pose enormous safety concerns as well. Modern approaches, in particular those using vector-based approaches have met with success in nonhuman primate models although success against Ebol...
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